Stem cells have the ability to turn into the cells. Still, as of June 2022, investigators have treated 50 of the 81 patients needed. The treatment of LUPUS disease with stem cells is recognized as a new method that scientists are working on.
#Stem cell treatment for lupus trial
The COVID-19 pandemic had a major effect on trial operations as investigators had to shut down enrollment for close to six months. One patient withdrew at the eight-week visit to seek other treatment for refractory disease.īased on these early promising results, the study has now transitioned to a Phase II trial, which will include up to 81 study participants. Steroids were also reduced to or maintained at 10mg or less per day in five of the six patients. This decline in SLEDAI was sustained for 52 weeks. Stem cell therapy has proven to be a reliable option for people who experience. Overall, five of the six women achieved a clinically meaningful decrease in lupus disease activity scores as measured by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). The conditioning treatment consists of rituximab, fludarabine, and cyclophosphamide to eliminate all the white blood cells from the blood and bone marrow. Lupus is commonly misdiagnosed since it’s a disease that can present itself in a wide variety of symptoms and although it’s not contagious it’s reported that more than 16,000 new cases of lupus are recorded annually across America. While some patients reported nausea, tingling and flushing, there were no serious adverse events in response to MSCs treatment. The new therapy for lupus will lead to profound healing activity. They also lead to long-term side effects and have to be administered for the entire life. They are agents that will suppress the immune response but bring only temporary improvements. Six women with refractory lupus were treated with MSCs derived from umbilical cord tissue. Does stem cell therapy give results for the autoimmune disease Currently, the traditional treatment for autoimmune conditions such as lupus includes steroids, cyclosporine, methotrexate, and infliximab.
In the preceding Phase I clinical trial, solely funded by the LFA, investigators at the Medical University of South Carolina sought to determine if MSCs therapy was safe to use in people with lupus. In 2018, the Lupus Foundation of America (LFA) agreed to provide $3.8 million to support a Phase II clinical study of stromal cells as a potential new therapy for lupus.
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